ea0035p779 | Obesity | ECE2014
Wang Baile
, Cheng Kenneth KY
, Li Xiaomu
, Lam Karen SL
, Xu Aimin
Introduction: We have previously demonstrated that APPL1 maintains glucose homeostasis by promoting both actions and secretion of insulin. Although APPL2 is a close homolog of APPL1, the physiological function of APPL2 is vaguely characterized. Thus, we generated a knockout (KO) mouse model in which APPL2 is deleted in pancreatic β-cells and hypothalamus (which is called APPL2 KO mice) to investigate its role in glucose and energy metabolism.Methods...